JAMES W. CURRAN, M.D., M.P.H.; BRUCE L. EVATT, M.D.; DALE N. LAWRENCE, M.D.
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In June 1981, five cases of Pneumocystis carinii pneumonia in young homosexual men were reported to the Centers for Disease Control (1). Since then, over 1000 definite cases of life-threatening opportunistic infections with or without Kaposi's sarcoma have been reported from 33 states and 13 foreign countries. Recognition that a similar pattern of immune dysfunction underlies each of these conditions resulted in their designation as the acquired immune deficiency syndrome.
From the outset, several factors implicated a transmissible agent as the cause of the severe alterations in immune regulation found in the syndrome. These lethal illnesses appeared suddenly and were
CURRAN JW, EVATT BL, LAWRENCE DN. Acquired Immune Deficiency Syndrome: The Past as Prologue. Ann Intern Med. 1983;98:401–403. doi: 10.7326/0003-4819-98-3-401
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Published: Ann Intern Med. 1983;98(3):401-403.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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