MORIE A. GERTZ, M.D.; ROBERT A. KYLE, M.D.; PHILIP R. GREIPP, M.D.
Twenty-two of 91 (24%) patients with primary systemic amyloidosis were functionally hyposplenic. This group, identified by blood smear findings, had a different survival distribution when compared with a normosplenic group (p < 0.0001). The peripheral blood smear was more sensitive than the splenic scan for a diagnosis of hyposplenism. Amyloidosis should be included in the differential diagnosis of acquired hyposplenism in the adult.
GERTZ MA, KYLE RA, GREIPP PR. Hyposplenism in Primary Systemic Amyloidosis. Ann Intern Med. ;98:475–477. doi: 10.7326/0003-4819-98-4-475
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Published: Ann Intern Med. 1983;98(4):475-477.
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