DENNIS M. KRIZEK, B.S.; MARGARET E. RICK, M.D.; SYBIL B. WILLIAMS, B.A.; HARVEY R. GRALNICK, M.D.
Von Willebrand's disease is a congenital bleeding disorder characterized by mild to severe bleeding, quantitative or qualitative factor VIII molecular defects, and a prolonged bleeding time (1). Type I disease is characterized by a quantitative reduction of factor VIII procoagulant activity, von Willebrand factor activity, and factor-VIII-related antigen. Although lower in quantity than normal, the factor-VIII-related antigen of type I von Willebrand's disease contains the full range of factor-VIII-related antigen multimers (0.8 X 106 to approximately 20 X 106 daltons) when assessed by sodium dodecyl sulfate agarose gel electrophoresis. Type II von Willebrand's disease is characterized by variable plasma levels
KRIZEK DM, RICK ME, WILLIAMS SB, GRALNICK HR. Cryoprecipitate Transfusion in Variant von Willebrand's Disease and Thrombocytopenia. Ann Intern Med. 1983;98:484–486. doi: 10.7326/0003-4819-98-4-484
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Published: Ann Intern Med. 1983;98(4):484-486.
Coagulopathies, Hematology/Oncology, Platelet Disorders.
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