BARNETT ZUMOFF, M.D.
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To the editor: The review (1) of the pharmacology of metoclopramide touched so briefly on its effects on plasma aldosterone levels (2) to imply that these effects are of no clinical significance. A recent patient of mine showed that this may not always be the case.
An 82-year-old man who had had a subendocardial infarct 8 weeks earlier and then developed mild and fairly stable congestive heart failure was treated with digoxin and mild salt restriction. One month after the infarct, the patient complained of upper abdominal distention, nausea, and anorexia, and was given a 2-week course of oral metoclopramide,
ZUMOFF B. Metoclopramide and Edema. Ann Intern Med. ;98:557. doi: 10.7326/0003-4819-98-4-557_1
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Published: Ann Intern Med. 1983;98(4):557.
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