Friedrich C. Luft, M.D.; David A. McCarron, M.D.
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Randomized clinical trials were advocated as the only reliable method to distinguish between therapies that are not overwhelmingly different. However, the application of such trials to assess the influence of dietary interventions in the treatment of hypertension is difficult. Alterations in dietary behavior are not easily achieved, and require a major degree of cooperation and enthusiasm on the part of the patient. Patient participation imparts a degree of self-selection, because lack of motivation will influence results. Nevertheless, the randomized design has been successfully used to address nutritional issues in hypertension. A cross-over design with random allocation was used in two
Luft FC, McCarron DA. Clinical Trials in Assessing the Effects of Nutrition on Blood Pressure. Ann Intern Med. ;98:882–883. doi: 10.7326/0003-4819-98-5-882_3
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Published: Ann Intern Med. 1983;98(5_Part_2):882-883.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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