RONALD A. SACHER, B.SC., M.B., B.CH., D.T.M.&H.; MATTHEW J. TEMPLE, PH.D.; ADRIANNE P. KELLY, M.D.
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To the editor: Distinctive chromosomal abnormalities in several histologic subtypes of non-Hodgkin's lymphomas have recently been described (1). The authors report two patients with immunoblastic lymphoma who had an unusual t(8;14) chromosomal rearrangement, a finding usually seen in Burkitt's lymphoma, and a rare translocation involving the terminal region of chromosome 8 and the short arm of chromosome 2 at band 2p13. That portion of chromosome 2 codes for the kappa immunoglobulin light chain. It is speculated that when DNA at the breakpoint of donor chromosome 8 (or 18) becomes contiguous with genes involved in immunoglobulin synthesis, lymphomatous transformation may occur.
SACHER RA, TEMPLE MJ, KELLY AP. Immunoblastic Leukemia and a Chromosome Marker. Ann Intern Med. ;99:411. doi: 10.7326/0003-4819-99-3-411_1
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Published: Ann Intern Med. 1983;99(3):411.
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