CARL V. VARTIAN, M.D.; DAVID M. SHLAES, M.D., PH.D.
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To the editor: We read the report of Wade and Meyers (1) with interest as we have also seen a case of transient neurologic deterioration associated with intravenous acyclovir.
A 56-year-old black woman was diagnosed as having hypereosinophilic syndrome in May 1982 when she presented with cough and dyspnea. Results of transbronchial and skin biopsies showed eosinophilic infiltrates. Prednisone and hydroxyurea were started. In June 1982, the patient had dysphagia. An esophagoscopic examination showed herpes simplex. On hospital day 8, intravenous acyclovir therapy was initiated at a dose of 250 mg/m2 body surface area every 8 hours. On the following
VARTIAN CV, SHLAES DM. Intravenous Acyclovir and Neurologic Effects. Ann Intern Med. ;99:568. doi: 10.7326/0003-4819-99-4-568_1
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Published: Ann Intern Med. 1983;99(4):568.
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