KHALID H. SHEIKH, M.D.; ALAN S. NIES, M.D.
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To the editor: With reference to the recent report by Chu and associates (1), we report another case of liver toxicity attributed to the use of the antidepressant medication, trazodone.
A 71-year-old woman was admitted for evaluation of malaise and jaundice. The patient had been started on trazodone, 50 mg/d, 2 weeks before the onset of symptoms. She was otherwise healthy and took no other medications or alcohol. On admission her bilirubin was 12 mg/dL (normal, less than 1 mg/dL); aspartate transaminase, 780 IU/L (normal less than 60 IU/L); and alkaline phosphatase, 1310 IU/L (normal, less than 120 IU/L). Negative
SHEIKH KH, NIES AS. Trazodone and Intrahepatic Cholestasis. Ann Intern Med. 1983;99:572. doi: 10.7326/0003-4819-99-4-572_1
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Published: Ann Intern Med. 1983;99(4):572.
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