MARY M. AUSTIN-SEYMOUR, M.D.; RICHARD T. HOPPE, M.D.; RICHARD S. COX, Ph.D.; SAUL A. ROSENBERG, M.D.; HENRY S. KAPLAN, M.D.
Fifty-two patients 60 to 75 years of age were treated for Hodgkin's disease at Stanford University between 1968 and 1980. Adequate staging was defined as including a lymphogram and staging laparotomy for stage I to III and a positive bone marrow or liver biopsy or other evidence of diffuse involvement of extralymphatic tissues for stage IV. Adequate treatment was defined as subtotal lymphoid irradiation for pathologic stages I to MA; total lymphoid irradiation for stages IIB to IIIA; and chemotherapy with or without irradiation for stages IIIB to IV. Twenty-four patients (46%) had advanced disease (IIIB to IV). Those patients who received appropriate treatment had a median survival of only 39 months. Of the 28 patients with limited disease (I to IIIA), 15 had laparotomy and adequate treatment. Thirteen did not have a laparotomy and 7 were treated with involved-field irradiation. The 5-year survival rate in the laparotomy-staged and adequately treated group was 86%, but in the clinically staged group, only 35% (p = 0.006).
AUSTIN-SEYMOUR MM, HOPPE RT, COX RS, et al. Hodgkin's Disease in Patients Over Sixty Years Old. Ann Intern Med. 1984;100:13–18. doi: 10.7326/0003-4819-100-1-13
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Published: Ann Intern Med. 1984;100(1):13-18.
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