S. DAVID FELDSHON, M.D.; RICHARD E. SAMPLINER, M.D.
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To the editor: To date, five "serious" reactions in patients have been attributed to administration of hepatitis B virus vaccine (1). In this letter, we describe one of those reactions.
A 31-year-old physician at the Arizona Health Sciences Center who did not have antibody to hepatitis B surface antigen (anti-HBs) received a standard initial dose of 20 µg of hepatitis B virus vaccine intramuscularly in November 1982. By 48 hours after the injection, he noted the onset of malaise and low-grade fever. At approximately 60 hours, he awoke with a generalized urticarial reaction. Over the next 5 days, the rash
FELDSHON SD, SAMPLINER RE. Reaction to Hepatitis B Virus Vaccine. Ann Intern Med. ;100:156–157. doi: 10.7326/0003-4819-100-1-156_2
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Published: Ann Intern Med. 1984;100(1):156-157.
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