HANS-GEORG GÜLLNER, M.D.
This content is PDF only. Please click on the PDF icon to access.
To the editor: In his editorial reviewing the role of prostaglandins in the control of blood pressure, Gerber (1) suggests that prostaglandin E2 may act indirectly as a vasodepressor agent by modulation of adrenergic nerve activity because prostaglandin E2 inhibits norepinephrine release from sympathetic nerve endings in response to stimulation in vitro. Gerber further states that "administration of nonsteroidal antiinflammatory agents has not resulted in elevated plasma catecholamine levels during basal or stimulated conditions."
Administration of drugs such as indomethacin or ibuprofen has in fact decreased rather than increased plasma and urinary catecholamines in normal subjects (2) as well as
GÜLLNER H. Prostaglandins and Blood Pressure. Ann Intern Med. 1984;100:163–164. doi: 10.7326/0003-4819-100-1-163_2
Download citation file:
Published: Ann Intern Med. 1984;100(1):163-164.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use