DAVID L. COHN, M.D.; KENT A. PENLEY, B.S.; FRANKLYN N. JUDSON, M.D.; CHARLES H. KIRKPATRICK, M.D.; CHARLES R. HORSBURGH JR., M.D.; KATHLEEN C. DAVIS, M.D.
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To the editor: A 31-year-old homosexual man was admitted to Denver General Hospital with Pneumocystis carinii pneumonia.
The patient's T-cell helper-to-suppressor ratio was 0.19 (normal, greater than 1.0). In-vitro lymphocyte responses to concanavalin A and pokeweed mitogen were reduced; responses to phytohemagglutinin were normal, and those to purified protein derivative, Candida, and tetanus were absent. The Clq binding of circulating immune complexes was normal (4.8%). Immunoglobin A was elevated (725 mg/dL); IgG and IgM were normal.
Intravenous trimethoprim-sulfamethoxazole, 240 and 1200 mg respectively every 6 hours, resulted in clinical and radiographic improvement but on the eighth day the patient had
COHN DL, PENLEY KA, JUDSON FN, et al. The Acquired Immunodeficiency Syndrome and a Trimethoprim-Sulfamethoxazole Adverse Reaction. Ann Intern Med. 1984;100:311. doi: 10.7326/0003-4819-100-2-311_1
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Published: Ann Intern Med. 1984;100(2):311.
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