ANDREW M. KAUNITZ, M.D.; CAROL J. R. HOGUE, PH.D.
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To the editor: Because progestogens can reduce estrogen-induced endometrial proliferation (1), there is much interest in these steroid hormones for treatment of menopausal women. We were, therefore, both surprised and discouraged to read the following statement (2) in the transcript of the UCLA Conference on estrogen replacement therapy: "Cyclical [estrogen] therapy and therapy with the intermittent use of progesterone have not as yet been shown to reduce the risk [of endometrial cancer] substantially." To the contrary, evidence shows that progestogens can eliminate the excess risk of endometrial cancer associated with estrogen use.
Dr. Henderson cited three studies to support
KAUNITZ AM, HOGUE CJR. Progestogens, Estrogen Therapy, and Endometrial Cancer. Ann Intern Med. ;100:316. doi: 10.7326/0003-4819-100-2-316_2
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Published: Ann Intern Med. 1984;100(2):316.
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