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The current treatment of asthma rests on three pillars: theophylline-containing compounds, specific beta2-adrenergic drugs, and corticosteroids. Compound E, or cortisone, was first isolated in 1939 by Kendall and coworkers, and by 1948 synthesis of sufficient quantities allowed Hench and associates to treat a woman with severe rheumatoid arthritis. Corticosteroids soon were being used in the management of severe asthma. However, the initial unreserved enthusiasm gave way to a more sobering view because of the potential for severe side effects. The introduction in Britain of inhaled corticosteroids dramatically changed opinions and medical usage, and Dr. Clark and his coauthors reassess steroid
Steroids in Asthma: A Reappraisal in the Light of Inhalation Therapy.. Ann Intern Med. 1984;100:329. doi: https://doi.org/10.7326/0003-4819-100-2-329_1
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Published: Ann Intern Med. 1984;100(2):329.
Asthma, Pulmonary/Critical Care.
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