ROBERT H. PALMER, M.D.
This content is PDF only. Please click on the PDF icon to access.
The results of the National Cooperative Gallstone Study reported in 1981 (1) were disappointing. After patients received chenodiol, 750 or 375 mg/d, or placebo for 2 years, complete dissolution of gallstones occurred in 13.5%, 5.2%, and 0.8%, respectively; partial dissolution (> 50%) occurred in 27.3%, 18.4%, and 10.2%. Two reasons for the poor response have been proposed (2): First, because the dose was suboptimal (as we now know) and for other reasons, bile may have been inadequately desaturated. Second, characteristics of the stones themselves may have prevented dissolution. If desaturation was inadequate, a longer period of treatment (or other measures)
PALMER RH. More on Chenodiol: Continued Treatment and Prevention of Recurrences. Ann Intern Med. ;100:450–451. doi: 10.7326/0003-4819-100-3-450
Download citation file:
Published: Ann Intern Med. 1984;100(3):450-451.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use