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The progress of medicine can be viewed in steps determined by methodologic advances, as well as in the development of new ideas. Landmarks in methodology include early morphologic descriptions, and osmotic fragility tests used in diagnosing and screening for beta thalassemia, so effectively used by Silvestroni and Bianco in Italy from the 1940s onward. The discovery in 1957 by Kunkel and coworkers that hemoglobin A2 is elevated in most beta-thalassemia heterozygotes started a further phase of investigation, based on both clinical and population studies. Then came rapid developments in the analysis of the hemoglobin molecule, and the concept of alpha
The Thalassemias.. Ann Intern Med. 1984;100:470–471. doi: https://doi.org/10.7326/0003-4819-100-3-470_3
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Published: Ann Intern Med. 1984;100(3):470-471.
Hematology/Oncology, Red Cell Disorders.
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