J. DUCOBU, M.D.
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To the editor: Recent reports suggest that naloxone hydrochloride can reverse alcoholic coma (1, 2), whereas at least one paper does not report this effect (3). We report a prospective, double-blinded, randomised, placebo-controlled study of the clinical value of naloxone for reversing ethanol intoxication.
We selected 19 consecutive unconscious patients with proven ethanol overdose. Eleven patients had pure ethanol intoxication, and 8 had ethanol and benzodiazepine or barbiturate intoxication. Toxicologic screening was done systematically. When the randomisation code was broken, 10 patients had been treated with 0.8 mg of intravenous naloxone and 8 with placebo. The alcohol values (mean ±
DUCOBU J. Naloxane and Alcohol Intoxication. Ann Intern Med. ;100:617–618. doi: 10.7326/0003-4819-100-4-617_3
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Published: Ann Intern Med. 1984;100(4):617-618.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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