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Medical genetics is a relatively new medical discipline that encompasses all ages, both sexes, and all organs. Genetic abnormalties are not only directly responsible for causing disease but may play a major role in determining a person's susceptibility to infectious, degenerative, and toxic disorders. Recent estimates place the number of genes required to program the development and successful functioning of a person at about 100 000. Because each gene is theoretically capable of mutating to a form that might cause disease, there should be at least one human disorder for each gene locus, or a minimum of 100 000 genetically
Mendelian Inheritance in Man: Catalogs of Autosomal Dominant, Autosomal Recessive, and X-linked Phenotypes.. Ann Intern Med. 1984;100:630. doi: https://doi.org/10.7326/0003-4819-100-4-630_1
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Published: Ann Intern Med. 1984;100(4):630.
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