J. BRUCE L. McCLAIN; W. RIPLEY BALLOU; SHANNON M. HARRISON; DONALD L. STEINWEG
To study antibiotic efficacy, 29 patients with leptospirosis were treated in a randomized, double-blinded fashion with doxycyline, 100 mg orally twice a day, or placebo. Therapy was given for 7 days in a hospital, and patients were followed for 3 weeks afterwards. Duration of illness before therapy and severity of illness were the same in both groups. Doxycycline reduced the duration of illness by 2 days and favorably affected fever, malaise, headache, and myalgias. Treatment prevented leptospiruria and had no adverse effects. Doxycyline is effective in therapy for patients with leptospirosis.
McCLAIN JBL, BALLOU WR, HARRISON SM, et al. Doxycycline Therapy for Leptospirosis. Ann Intern Med. 1984;100:696–698. doi: 10.7326/0003-4819-100-5-696
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Published: Ann Intern Med. 1984;100(5):696-698.
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