A. MANOHARAN, M.D.
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To the editor: I read with interest the article by Ahn and coworkers (1) on slow infusion of vinca alkaloids in the treatment of idiopathic thrombocytopenic purpura, which reported good to excellent responses in 17 of 24 patients. In the past 2 years I have treated 5 women with slow infusions of vincristine at a standard dose of 2 mg given over a 4-hour period at weekly intervals for 4 weeks. Two patients responded with sustained increases in platelet counts, for 4 months and 20 months, respectively. There were no untoward clinical or laboratory side effects associated with vincristine therapy.
MANOHARAN A. Slow Infusion of Vinca Alkaloids in Idiopathic Thrombocytopenic Purpura. Ann Intern Med. 1984;100:921. doi: 10.7326/0003-4819-100-6-921_1
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Published: Ann Intern Med. 1984;100(6):921.
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