RICHARD GANNON, PHARM, D.; STEPHEN SULLMAN, B.S.; R. MAX LEVY, M.S.; JAMES GROBER, M.D.
This content is PDF only. Please click on the PDF icon to access.
To the editor: Vidarabine's major metabolite is hypoxanthine arabinoside. The metabolite is excreted renally and biotransformed via the xanthine oxidase pathway (1, 2). Theophylline is metabolized by the hepatic miscrosomal enzymes and xanthine oxidase (3). We suspect that when vidarabine and theophylline are used concomitantly, theophylline metabolism is inhibited.
A 62-year-old woman weighing 45 kg was admitted with suspected intraabdominal sepsis. She had a history of congestive heart failure and chronic obstructive pulmonary disease. Therapy was begun with ampicillin, gentamicin, clindamycin, digoxin, and intravenous aminophylline. Sepsis was due to Clostridia perfringens from a perforated gallbladder. The patient's therapy was eventually
GANNON R, SULLMAN S, LEVY RM, et al. Possible Interaction Between Vidarabine and Theophylline. Ann Intern Med. 1984;101:148–149. doi: 10.7326/0003-4819-101-1-148_2
Download citation file:
Published: Ann Intern Med. 1984;101(1):148-149.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use