MARCOS A. SOUZA LIMA, M.D.
Ranitidine (Zantac; Glaxo, Incorporated, Research Triangle Park, North Carolina) is a relatively new H2-receptor antagonist with a potency fourfold to eightfold that of Cimetidine. The debate on the comparative values of these two drugs has intensified (1-3). Minor side effects, such as headaches, skin rash, and dizziness, occur in about 3% of patients receiving ranitidine, but serious toxicity is rare. I report a case of hepatitis occurring after the use of ranitidine.
A 77-year-old woman was hospitalized for fever, chills, nausea, and occasional vomiting. Twelve days before admission she had begun taking ranitidine, 150 mg twice daily, for treatment of
SOUZA LIMA MA. Hepatitis Associated with Ranitidine. Ann Intern Med. 1984;101:207–208. doi: 10.7326/0003-4819-101-2-207
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Published: Ann Intern Med. 1984;101(2):207-208.
Gastroenterology/Hepatology, Liver Disease.
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