HANS-GEORG GÜLLNER, M.D.; MARIAN S. KAFKA, Ph.D.; JOHN R. GILL Jr., M.D.
Hypokalemia is associated with resistance to the physiologic effects of vasopressin, parathyroid hormone, and norepinephrine (1-4). The physiologic actions of each of these hormones are mediated by cyclic adenosine monophosphate (AMP). To determine whether this resistance is caused by impaired generation of cyclic AMP by the target tissues, the regulation of adenylate cyclase was studied in blood platelets, an easily accessible tissue. Cyclic AMP production was measured in platelet preparations from two groups of female patients, those with Bartter's syndrome and those with other disorders involving hypokalemia, such as psychogenic vomiting and the syndrome of hypokalemia with renal tubulopathy ("familial
GÜLLNER H, KAFKA MS, GILL JR. Insensitivity of Platelet Adenylate Cyclase to Prostaglandin E1 in Patients with Hypokalemic Diseases. Ann Intern Med. ;101:342–343. doi: 10.7326/0003-4819-101-3-342
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Published: Ann Intern Med. 1984;101(3):342-343.
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