M. HENRY GAULT, M.D.; SUDESH C. VASDEV, PH.D.; LINDA L. LONGERICH, M.SC.
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To the editor: An endogenous digoxin-like substance has recently been described in the blood of neonates (1), and we read with interest two recent reports in the Annals. Graves and colleagues (2) found a similar substance in concentrations up to 1 ng/mL by radioimmunoassay in patients with renal impairment, and Heazlewood and colleagues(3), using a fluorescence polarization immunoassay (TDX System, Abbott Laboratories, North Chicago, Illinois), found no detectable digoxin immunoreactivity in 60 patients with acute or chronic renal failure. We report what may be an additional endogenous digoxin-like substance in three patients with combined hepatic and acute renal failure.
GAULT MH, VASDEV SC, LONGERICH LL. Endogenous Digoxin-like Substance(s) and Combined Hepatic and Renal Failure. Ann Intern Med. ;101:567–568. doi: 10.7326/0003-4819-101-4-567_2
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Published: Ann Intern Med. 1984;101(4):567-568.
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