JOHN H. REYNOLDS, M.D.; NEIL I. KAMINSKY, M.D.; DAVID S. SCHADE, M.D.; R. PHILIP EATON, M.D.
An insulinoma may be difficult to diagnose when roentgenograms and hormonal test results, such as with proinsulin, are normal. Autonomous insulin secretion is characteristic of this tumor, but administration of exogenous insulin to test for autonomy may cause severe hypoglycemia. The euglycemic glucose clamp technique is a research method that has not yet been applied to clinical medicine (1). With the aid of a minicomputer, we used this technique to safely detect autonomous insulin secretion in a patient susceptible to hypoglycemic seizures. After autonomous insulin secretion was documented, a laparotomy showed a 1.5-cm-diameter insulinoma. Surgical removal of the tumor resulted
REYNOLDS JH, KAMINSKY NI, SCHADE DS, EATON RP. Use of a Computerized Glucose Clamp Technique to Diagnose an Insulinoma. Ann Intern Med. 1984;101:648–649. doi: 10.7326/0003-4819-101-5-648
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Published: Ann Intern Med. 1984;101(5):648-649.
Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology, Pancreatic Cancer, Pancreatic Disease.
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