Glycosylated hemoglobins represent stable ketoneamine or aldehyde-amine linkages formed by a nonenzymatic, post-translational process of glycosylation of hemoglobin that occurs throughout the lifespan of the erythrocyte (1). The finding that glycosylated hemoglobin levels may be elevated up to three times normal in persons with diabetes mellitus led to consideration of glycosylated hemoglobin measurement as an aid for diagnosing and managing these patients (2-4).
Hemoglobin A is the major component of hemoglobin, comprising approximately 90% of hemoglobin found in the erythrocytes of average normal adults. Some glycosylated hemoglobins are negatively charged and thus migrate more quickly than hemoglobin A on cation
Glycosylated Hemoglobin Assays in the Management and Diagnosis of Diabetes Mellitus. Ann Intern Med. 1984;101:710–713. doi: https://doi.org/10.7326/0003-4819-101-5-710
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Published: Ann Intern Med. 1984;101(5):710-713.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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