JAMES H. KELLER, Pharm. D.; IRA WEINSTEIN, M.D.
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To the editor: Jackson and associates (1) reported five patients who developed a microangiopathic hemolytic anemia with renal insufficiency and thrombocytopenia after treatment with cisplatin, bleomycin, and a vinca alkaloid. Of the five patients, one had thrombotic thrombocytopenia purpura and the other four developed the hemolytic-uremic syndrome. Two patients had an indolent course and three patients died of complications related to the syndrome. All patients had minimal or nondetectable disease at the onset of the thrombotic microangiopathy.
A number of investigators (2, 3) have also reported the syndrome in other types of malignant diseases treated with different chemotherapeutic regimens. Microangiopathic
KELLER JH, WEINSTEIN I. Registry for the Microangiopathic Hemolytic Syndrome Associated with Cancer Chemotherapy. Ann Intern Med. ;101:716. doi: 10.7326/0003-4819-101-5-716_1
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Published: Ann Intern Med. 1984;101(5):716.
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