PlETER E. POSTMUS; HANNY HAAXMA-REICHE; LOUK M. VENCKEN; AAFKE F. MEINESZ; DIRK TH. SLEIJFER; NANNO H. MULDER
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To the editor: The prognosis of patients with small-cell lung cancer has been improved by combination chemotherapy; however, central nervous system involvement is still an unfavorable prognostic factor (1), probably due to insufficient penetration of cytostatic drugs through the blood-brain barrier. Radiotherapy is at present the only treatment for brain metastases due to small-cell lung cancer. For brain metastases developing or recurring after radiotherapy, no effective therapy is available. In a phase I study (2) of etoposide (VP16-213), therapeutic effects on central nervous system metastases and detectable levels of etoposide in the cerebrospinal fluid were found (3). We report the
POSTMUS PE, HAAXMA-REICHE H, VENCKEN LM, et al. Remission of Brain Metastases from Small-Cell Lung Cancer After High-Dose Chemotherapy. Ann Intern Med. 1984;101:717. doi: https://doi.org/10.7326/0003-4819-101-5-717
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Published: Ann Intern Med. 1984;101(5):717.
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