MARVIN J. FELDMAN, M.S.; PAUL F. SOUNEY, M.S.; MARY BETH DRISCOLL, B.S.
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To the editor: Several recent reports (1-4) have shown a potential for toxicity of solvents in most commercially available parenteral nitroglycerin products. Various concentrations of both propylene glycol and ethanol are found in four of five currently available commercial brands of this preparation. Such cosolvent systems provide greater solubility of nitroglycerin, resulting in an increased drug solution concentration (5 mg/mL). Because this drug is generally further diluted when administered intravenously, more dilute concentrations of the stock solution are acceptable.
In response to reports of solvent intoxication at our institution (1-3), we investigated potential alternatives to products containing ethanol and propylene
FELDMAN MJ, SOUNEY PF, DRISCOLL MB. Solvent Intoxication with Parenteral Nitroglycerin. Ann Intern Med. 1985;102:134. doi: 10.7326/0003-4819-102-1-134_1
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Published: Ann Intern Med. 1985;102(1):134.
DOI: 10.7326/0003-4819-102-1-134_1