RICHARD N. FEDORAK, M.D.; MICHAEL FIELD, M.D.; EUGENE B. CHANG, M.D.
Stimulation of alpha2-adrenergic receptors on enterocytes promotes fluid and electrolyte absorption and inhibits anion secretion. Loss of adrenergic innervation may play a role in impaired intestinal fluid and electrolyte absorption in diabetic patients with autonomic neuropathy. Clonidine, an alpha2-adrenergic agonist, was used to treat three patients with "idiopathic" diabetic diarrhea after other treatments had failed: The volume of diarrhea declined significantly (p < 0. 01). Diarrhea recurred when the drug was withdrawn, but the patient's condition improved again when Clonidine treatment was reintroduced. Hypotension did not occur as a side effect presumably because of the autonomic neuropathy of these patients.
FEDORAK RN, FIELD M, CHANG EB. Treatment of Diabetic Diarrhea with Clonidine. Ann Intern Med. 1985;102:197–199. doi: https://doi.org/10.7326/0003-4819-102-2-197
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Published: Ann Intern Med. 1985;102(2):197-199.
Cardiology, Coronary Risk Factors, Diabetes, Diarrhea, Endocrine and Metabolism.
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