STEVEN L. BERK, M.D.
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To the editor: The study by Smith and associates (1) comparing cefotaxime with nafcillin and tobramycin in serious bacterial infection used only patients who would "otherwise have been treated with the combination of a semisynthetic penicillin and an aminoglycoside." Yet patients enrolled in the study were shown to have Pseudomonas aeruginosa and other gram-negative pneumonias, pneumococcal bacteremia, anerobic decubitus ulcers, and Haemophilus influenzae infection.
The study reminds us that our diagnostic capabilities have lagged far behind our progress in antibiotic development. I assume that if this group had anticipated that their patients would have gram-negative pneumonia, enterococcal infection, anerobic soft
BERK SL. Cefotaxime and Nafcillin-Tobramycin. Ann Intern Med. ;102:275–276. doi: 10.7326/0003-4819-102-2-275_3
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Published: Ann Intern Med. 1985;102(2):275-276.
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