WILLIAM M. BUTLER, M.D.; WILLIAM A. ARMSTRONG, M.D.
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To the editor: Sinus histiocytosis with massive lymphadenopathy was described as a clinical entity by Rosai and Dorfman (1) in 1969. This disease is usually self-limited and occurs in the first 20 years of life. It is characterized by prominent adenopathy, fever, leukocytosis, anemia, and hypergammaglobulinemia. The extranodal involvement usually involves the orbit, eyelid, upper respiratory tract, or skin (2).
We have recently seen a 18-year-old black woman who presented in March 1981 with sinus histiocytosis with massive lymphadenopathy. She developed a hyperviscosity syndrome in June 1981 (3). Prominent orbital swelling prompted a biopsy in October 1981, which showed involvement
BUTLER WM, ARMSTRONG WA. Pregnancy and Sinus Histiocytosis with Massive Lymphadenopathy. Ann Intern Med. 1985;102:278. doi: https://doi.org/10.7326/0003-4819-102-2-278
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Published: Ann Intern Med. 1985;102(2):278.
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