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For immunologists of the past 2 decades, "going for the gold" has meant the elucidation of the genetic and biochemical mechanisms responsible for the specificity and diversity of antibodies. Some early researchers have been honored as Nobel laureates, and others will indubitably be so recognized in subsequent years. The central question has been how does a multicellular organism as complex as man generate proteins on demand that combine selectively with one of the million to billion different foreign structures presented to it. The search for the answer, as scientifically chronicled by Kindt and Capra, has challenged and, in some cases,
The Antibody Enigma.. Ann Intern Med. ;102:280. doi: 10.7326/0003-4819-102-2-280_2
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Published: Ann Intern Med. 1985;102(2):280.
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