STUART C. GORDON, M.D.; LENNOX J. JEFFERS, M.D.; MARIA D. DE MEDINA, B.S.; K. RAJENDER REDDY, M.D.; EUGENE R. SCHIFF, M.D.
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To the editor: Fulminant hepatitis B, characterized by deepening jaundice, encephalopathy, coagulopathy, and coma, is an uncommon and frequently fatal complication of a common viral disease. Because the absence of hepatitis B surface antigen (HBsAg) does not preclude the diagnosis of fulminant type B hepatitis, the serum IgM antibody to hepatitis B core antigen (anti-HBc) has been advocated as a useful diagnostic variable. We report the cases of two patients with fulminant hepatitis B, with strongly positive antibody to the hepatitis B surface antigen (anti-HBs) at or near the time of admission, in whom the IgM anti-HBc proved to be
GORDON SC, JEFFERS LJ, DE MEDINA MD, et al. Immunoglobulin M Antibody to Hepatitis B Core Antigen and Fulminant Hepatitis B. Ann Intern Med. 1985;102:415–416. doi: 10.7326/0003-4819-102-3-415_3
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Published: Ann Intern Med. 1985;102(3):415-416.
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