F. JOHN SERVICE, M.D.
This content is PDF only. Please click on the PDF icon to access.
To the editor: In a recent issue, Reynolds and colleagues (1) reported the case of a patient with an insulinoma in which a computerized euglycemic glucose clamp was used as a diagnostic procedure to assess C-peptide suppression. Reduced C-peptide suppressibility to insulin-induced hypoglycemia is a well-documented feature of insulinomas. Hyperinsulinemia concurrent with euglycemia, the conditions of the clamp used by these authors, probably suppresses C-peptide to a small extent in healthy persons (2), but this effect has not been seen by all investigators (3). The effect of hyperinsulinemia alone on C-peptide suppression in insulinomas is unknown. The conclusion by Reynolds
SERVICE FJ. Diagnosis of Insulinoma and the Euglycemic Hyperinsulinemic Clamp Technique. Ann Intern Med. 1985;102:417–418. doi: https://doi.org/10.7326/0003-4819-102-3-417
Download citation file:
Published: Ann Intern Med. 1985;102(3):417-418.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use