JON A. GREEN, M.D., Ph.D.; SPOTSWOOD L. SPRUANCE, M.D.; GAY WENERSTROM, R.N.; MICHAEL W. PIEPKORN, M.D., Ph.D.
Recurrent herpes simplex virus infection predisposes to the development of erythema multiforme in some persons (1) and can lead to a pattern of recurrent erythema multiforme and disabling morbidity. Recent reports of the safety and efficacy of oral acyclovir for the prophylaxis of recurrent herpes virus infections (2-4) suggest a similar application for the prevention of herpes virusrelated erythema multiforme.
A 26-year-old white man, a professional housepainter, had recurrent labial herpes virus infections for 12 years with a stable pattern of three to five episodes a year. At age 24 he began having accelerated recurrences at monthly or bimonthly intervals.
GREEN JA, SPRUANCE SL, WENERSTROM G, PIEPKORN MW. Post-Herpetic Erythema Multiforme Prevented with Prophylactic Oral Acyclovir. Ann Intern Med. ;102:632–633. doi: 10.7326/0003-4819-102-5-632
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Published: Ann Intern Med. 1985;102(5):632-633.
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