PAUL R. BILLINGS, M.D.
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To the editor: Alpha1 antitrypsin and antithrombin III belong to a family of plasma proteins known as the serum antiproteases (or serum protease inhibitors). The antiproteases have distinctly different physiologic functions and are coded for by unlinked genes (alpha1 antitrypsin on chromosome 14; antithrombin III on chromosome 1), although they are genetically related via a common ancestral gene from which the genes for angiotensinogen and ovalbumin also have arisen (1). Recently, a mutant alpha1 antitrypsin protein (A1AT Pittsburgh) has been shown to affect functions usually regulated by antithrombin III, proving that a de-novo genetic change at the alpha1 antitrypsin locus
BILLINGS PR. Hypercoagulability, Hyperlipidemia, and Serum Antiproteases. Ann Intern Med. ;102:724. doi: 10.7326/0003-4819-102-5-724_1
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Published: Ann Intern Med. 1985;102(5):724.
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