Skip Navigation
Menu
Letters |1 June 1985

Imidazoles, Ketoconazole, Amphotericin B, and Candida guilliermondii

GARY WILSON, M.D.; JAMES E. PEACOCK JR., M.D.

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • Bowman Gray School of Medicine of Wake Forest University
    ;
    Winston-Salem, NC 27103
×
FULL TEXT

This content is PDF only. Please click on the PDF icon to access.

Abstract

To the editor: The case of amphotericin-B-resistant Candida guilliermondii described by Dick and colleagues (1) certainly epitomizes the growing problem of fungal disease and its therapy in the immunocompromised patient. However, the report also left several questions unanswered.

One question relates to the effect of prior imidazole exposure on fungal sensitivity to amphotericin B. The antifungal activity of amphotericin B is mediated through binding of the drug to ergosterol within fungal cell walls (2). In contrast, imidazoles inhibit ergosterol synthesis. Thus, exposure to imidazoles may result in the development of progressive resistance to amphotericin B because of decreasing ergosterol content

FULL TEXT
PDF
Not Available
Citations
Citation

WILSON G, PEACOCK JE. Imidazoles, Ketoconazole, Amphotericin B, and Candida guilliermondii. Ann Intern Med. 1985;102:866. doi: 10.7326/0003-4819-102-6-866_1

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 1985;102(6):866.

DOI: 10.7326/0003-4819-102-6-866_1

3 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×