SUSAN A. FUHRMAN, M.D.; JOHN H. ECKFELDT, M.D., Ph.D.
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To the editor: We read with interest Anderson and coworker's study (1) of hyponatremia in hospitalized patients. The high frequency of the so-called syndrome of inappropriate secretion of antidiuretic hormone (SIADH) as a cause of hyponatremia was intriguing and well documented. However, we wish to point out a common clinical misconception regarding sodium measurement by ion-selective electrodes.
Anderson and coworkers state that spurious hyponatremia due to hyperlipidemia or hyperproteinemia was excluded because they used a Beckman analyzer (Beckman Instruments, Fullerton, California) that uses ion-selective electrodes for sodium determinations. Methods of using ion-selective electrodes are classified as either direct, when serum,
FUHRMAN SA, ECKFELDT JH. Hyponatremia and Ion-Selective Electrodes. Ann Intern Med. ;102:872. doi: 10.7326/0003-4819-102-6-872_1
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Published: Ann Intern Med. 1985;102(6):872.
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