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In the late 1960s, academic specialists in infectious diseases opposed the use of antimicrobial agents in surgical wound prophylaxis as poor science, a poor concept, and a cover up for poor surgical technique; they were wrong. Over the next 10 years, using appropriately designed experimental and clinical studies, academic and practicing surgeons developed valuable insights into the pathogenesis of surgical wound infection. Appropriately administered antimicrobial agents were shown to be highly successful (and cost effective) in preventing postsurgical wound infections. Outstanding pioneer work was done on the effect of nutrition on the immune system and wound healing. Unfortunately, the extension
Manual on Control of Infection in Surgical Patients.. Ann Intern Med. 1985;102:881. doi: https://doi.org/10.7326/0003-4819-102-6-881_4
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Published: Ann Intern Med. 1985;102(6):881.
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