BARBARA R. REED, M.D.; J. CLARK HUFF, M.D.; STEPHEN K. JONES, M.D.; PAUL W. ORTON, M.D.; LELA A. LEE, M.D.; DAVID A. NORRIS, M.D.
Photosensitive eruptions with clinical and histologic features of subacute cutaneous lupus erythematosus and antibodies to SS-A(Ro) antigen occurred in five patients taking hydrochlorothiazide. After drug therapy was discontinued, the eruptions cleared. In one patient anti-SS-A antibodies disappeared after discontinuation of thiazide, and in another rechallenge with hydrochlorothiazide produced an acute dermatitis with a photodistribution. These eruptions may represent a new type of photosensitive drug reaction in which the photoactive drug may be synergistic with anti-SS-A antibody in producing cutaneous lesions of photosensitive subacute cutaneous lupus erythematosus.
REED BR, HUFF JC, JONES SK, et al. Subacute Cutaneous Lupus Erythematosus Associated with Hydrochlorothiazide Therapy. Ann Intern Med. 1985;103:49–51. doi: https://doi.org/10.7326/0003-4819-103-1-49
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Published: Ann Intern Med. 1985;103(1):49-51.
Lupus Erythematosus, Rheumatology.
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