PAUL S. HECKERLING, M.D.
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To the editor: Nephrotic syndrome, secondary to immune-complex glomerulonephritis, has been reported in association with several types of extrarenal carcinomas (1-3). Only one case of nephrotic syndrome associated with carcinoma of the esophagus has been described (4). The renal lesion in that case proved to be membranoproliferative glomerulonephritis. We report the case of a patient with esophageal cancer and nephrotic syndrome secondary to membranous nephropathy.
A previously healthy 65-year-old man presented with odynophagia and dysphagia for solid foods, accompanied by ankle swelling, of 6 months' duration. Physical findings included 2+ pitting edema of both legs but were otherwise unremarkable. Esophagoscopy
HECKERLING PS. Esophageal Carcinoma with Membranous Nephropathy. Ann Intern Med. 1985;103:474. doi: https://doi.org/10.7326/0003-4819-103-3-474_1
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Published: Ann Intern Med. 1985;103(3):474.
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