HALIL DEGERTEKIN, M.D.; ATILLA ERTAN, M.D.; ROBERT D. YATES, Ph.D.; KEITH VAN METER, M.D.; AKDAMAR KEMAL, M.D.
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To the editor: McCord's recent article has drawn attention to the importance of oxygen-derived free radicals in postischemic tissue injury (1). Evidence implicating oxygen radicals in inflammatory disorders of the gastrointestinal tract has also been presented (2).
Because the role of oxygen-free radicals in the pathogenesis of acute pancreatitis is unknown, we investigated the effect of hyperbaric oxygen therapy and allopurinol, a xanthine oxidase inhibitor (a putative scavenger of the hydroxyl radical), on female CD-1 mice with acute pancreatitis induced by a choline-deficient, ethionine-supplemented diet. One hundred twenty mice were fed the test diet or a normal diet for 48
DEGERTEKIN H, ERTAN A, YATES RD, METER KV, KEMAL A. Hyperbaric Oxygen, Allopurinol, and Diet-Induced Acute Pancreatitis. Ann Intern Med. 1985;103:474. doi: 10.7326/0003-4819-103-3-474_3
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Published: Ann Intern Med. 1985;103(3):474.
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