RANDY K. BOTTNER, M.D.; CARL J. TULLIO, R.Ph.
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To the editor: We want to report a case of metoclopramide-induced depression in a 19-year-old woman with an 11-year history of insulin-dependent diabetes.
The patient first developed symptoms of diabetic gastroparesis in April 1984, while under the care of another physician. Unknown to us, a trial of metoclopramide at that time produced subjective symptoms of depression. The drug therapy was discontinued, her symptoms resolved, and she was not rechallenged.
Her symptoms of diabetic gastroparesis abated spontaneously but recurred in March 1985. Metoclopramide was initiated at a dose of 10 mg before meals and at bedtime, resulting in severe depression manifested
BOTTNER RK, TULLIO CJ. Metoclopramide and Depression. Ann Intern Med. ;103:482. doi: 10.7326/0003-4819-103-3-482_1
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Published: Ann Intern Med. 1985;103(3):482.
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