TIMOTHY C. WILLIAMS, M.D.; LAWRENCE A. FROHMAN, M.D.
Hemochromatosis is a disorder characterized by the deposition of iron in various tissues and organs. Studies have shown altered pituitary target organ dysfunction associated with this disease, the commonest being hypogonadotrophic testicular failure (1-7). Abnormalities of cortisol (2, 6, 7), growth hormone (2, 3, 6, 7), prolactin (2), and thyroid-stimulating hormone secretion (2, 3, 6, 7) have also been reported. It has been implied that iron deposition in the pituitary gland leads to impaired pituitary hormone secretion with subsequent target organ failure (7, 8). There are frequent findings of testicular atrophy with low levels of gonadotrophins unresponsive to single injections
WILLIAMS TC, FROHMAN LA. Hypothalamic Dysfunction Associated with Hemochromatosis. Ann Intern Med. ;103:550–551. doi: 10.7326/0003-4819-103-4-550
Download citation file:
Published: Ann Intern Med. 1985;103(4):550-551.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use