WILLIAM B. HARWELL, M.D.
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To the editor: Hyperimmunoglobulin E syndrome, or Job's syndrome, consists of recurrent pyogenic infections (usually staphylococcal), elevated levels of IgE, eczema, a cellular defect in chemotaxis, and sometimes, peripheral blood eosinophilia (1). Although both urticaria (2) and anaphylaxis (3), manifestations of systemic mastocytosis, have been described in association with this syndrome, their association has not been well described. We describe the case of a patient who has features of both the hyperimmunoglobulin E syndrome and systemic mastocytosis.
In June 1977 a 32-year-old white woman sought medical attention for a particularly severe episode of pruritus. Physical findings included chronic and generalized
HARWELL WB. Mastocytosis and the Hyperimmunoglobulin E Syndrome. Ann Intern Med. ;103:641. doi: 10.7326/0003-4819-103-4-641_1
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Published: Ann Intern Med. 1985;103(4):641.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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