ADRIAN O. VLADUTIU, M.D., Ph.D.
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To the editor: The article by Kessler and colleagues (1) is of general interest because it shows, once again, that antibodies to hepatitis B surface antigen (anti-HBs), at least as they are currently detected in clinical laboratories with commercial reagents, are sometimes cross-reacting antibodies. I would like to emphasize two points: higher sample ratio units (ratio of counts per minute of the tested sample over the mean of negative control samples) are not proof of monospecificity for hepatitis B surface antigen (HBsAg) (2, 3), and the absorption (neutralization) by HBsAg also does not rule out cross-reactivity of anti-HBs. Indeed, one
VLADUTIU AO. Antibodies to Hepatitis B Surface Antigen. Ann Intern Med. ;103:806–807. doi: 10.7326/0003-4819-103-5-806_2
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Published: Ann Intern Med. 1985;103(5):806-807.
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