MARK M. CHUNG, M.D.; KOTA G. CHETTY, M.D.; DENNIS JEROME, M.D.
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To the editor: Several drugs are known to cause bronchospasm (1), and the mechanisms responsible for this effect are many. Cholinergic mechanisms are an important pathway influencing airways reactivity (2). The respiratory tree is supplied by parasympathetic postganglionic nerves and the terminals are largely cholinergic. Metoclopramide (methoxy 2-chloro 5-procainamide) has the ability to release acetylcholine from postganglionic cholinergic nerve terminals and could precipitate bronchospasm; however, such an adverse effect has not been reported or even suggested (3). We recently saw bronchospastic reactions in an asthmatic patient after he ingested this drug.
A 58-year-old man diagnosed by history as having asthma,
CHUNG MM, CHETTY KG, JEROME D. Metoclopramide and Asthma. Ann Intern Med. ;103:809. doi: 10.7326/0003-4819-103-5-809_1
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Published: Ann Intern Med. 1985;103(5):809.
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