R. JOHNSON, M.D.; J. DOUGLAS, M.D.; L. COREY, M.D.; HARVEY KRASNEY, M.D.
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To the editor: We write to share our experience of a patient treated with acyclovir and meperidine with serious consequences.
A 54-year-old man with stage IVA Hodgkin's disease in remission was admitted with localized herpes zoster of the left thigh. Treatment was initiated with intravenous acyclovir, 875 mg (500 mg/m2) given over 1 hour at 8-hour intervals. Intramuscular meperidine, oral methadone, and carbidopa-levodopa were administered for control of cutaneous pain, and intravenous fluids were provided at a rate of 100 mL/h. On the second day the patient developed nausea, vomiting, and confusion. The carbidopa-levodopa (cumulative, 30 mg of carbidopa and
JOHNSON R, DOUGLAS J, COREY L, KRASNEY H. Adverse Effects with Acyclovir and Meperidine. Ann Intern Med. ;103:962–963. doi: 10.7326/0003-4819-103-6-962_3
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Published: Ann Intern Med. 1985;103(6_Part_1):962-963.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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