KENNETH H. MAYER, M.D.; ANNE M. STODDARD, Sc.D.; JANE McCUSKER, M.D., Dr.P.H.; DAVID AYOTTE, M.S.P.H.; ROBERTA FERRIANI, B.A.; JEROME E. GROOPMAN, M.D.
A cohort of 215 asymptomatic homosexually active men from a Boston community health center are being prospectively followed to assess the natural history of the human T-lymphotropic virus type III (HTLV-III) infection. To determine if certain asymptomatic persons who are HTLV-III antibody negative may be viremic, an algorithm was developed that defined high-risk characteristics (a sexual partner with the acquired immunodeficiency syndrome [AIDS]; more than 100 homosexual partners; or leukopenia, lymphopenia, neutropenia, or thrombocytopenia). Of 33 asymptomatic homosexual men who did not have antibody to HTLV-III and whose cases have not been previously reported, 2 had HTLV-III recovered from their lymphocytes. Clinical, behavioral, and hematologic data from seronegative persons did not distinguish between those with negative or positive viral cultures. Asymptomatic carriage of HTLV-III in high-risk seronegative persons underscores the need to base preventive educational strategies and behavioral modification on the assessment of risk factors and not solely on the results of HTLV-III antibody screening.
MAYER KH, STODDARD AM, McCUSKER J, et al. Human T-Lymphotropic Virus Type III in High-Risk, Antibody-Negative Homosexual Men. Ann Intern Med. 1986;104:194–196. doi: 10.7326/0003-4819-104-2-194
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Published: Ann Intern Med. 1986;104(2):194-196.
HIV, Infectious Disease.
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